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San Francisco (/ˌsæn frənˈsɪskoʊ/; Spanish for "Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California in the United States. The city proper is the fourth most populous in California and 17th most populous in the United States, with 815,201 residents as of 2021. It covers a land area of 46.9 square miles (121 square kilometers), at the end of the San Francisco Peninsula, making it the second most densely populated large U.S. city after New York City, and the fifth most densely populated U.S. county, behind only four of the five New York City boroughs. Among the 91 U.S. cities proper with over 250,000 residents, San Francisco was ranked first by per capita income (at $160,749) and sixth by aggregate income as of 2021. Colloquial nicknames for San Francisco include SF, San Fran, The City, Frisco, and Baghdad by the Bay.

San Francisco and the surrounding San Francisco Bay Area are a global center of economic activity and the arts and sciences, spurred by leading universities, high-tech, healthcare, FIRE, and professional services sectors. As of 2020, the metropolitan area, with 6.7 million residents, ranked 5th by GDP ($874 billion) and 2nd by GDP per capita ($131,082) across the OECD countries, ahead of global cities like Paris, London, and Singapore. San Francisco anchors the 13th most populous metropolitan statistical area in the United States with 4.6 million residents, and the fourth-largest by aggregate income and economic output, with a GDP of $669 billion in 2021. The wider San Jose–San Francisco–Oakland, CA Combined Statistical Area is the fifth most populous, with 9.5 million residents, and the third-largest by economic output, with a GDP of $1.25 trillion in 2021. In the same year, San Francisco proper had a GDP of $236.4 billion, and a GDP per capita of $289,990. San Francisco was ranked seventh in the world and third in the United States on the Global Financial Centres Index as of March 2022.

Wuxue City, a county-level city under the jurisdiction of Huanggang City, Hubei Province, China, is an important part of Wuhan city circle and a port city in the middle reaches of the Yangtze River. The city has a total area of 1246 square kilometers and has jurisdiction over 12 towns and 342villages (communities), with an area of 500000 mu of arable land and a total population of 830000. Wuxue City is located on the north bank of the middle reaches of the Yangtze River, the southern foot of the Dabie Mountains and the edge of eastern Hubei. It has always been the "thoroughfare of three provinces and seven counties" in the adjoining areas of Hubei, Anhui and Jiangxi. Wuxue City, formerly known as Guangji County, was called "the Kingdom of Buddha" in ancient times, meaning "wide application of Buddhist dharma and universal aid to sentient beings". In 1987, with the approval of the State Council, the county was withdrawn and the city was established. Wuxue City has Wuxue Port, one of the ten deepwater ports on the Yangtze River, where the Beijing-Kowloon Railway, China's longest railway, and the entrance and exit of Shanghai-Chongqing Expressway, the longest highway in China, meet here.
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